How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD

Kimberly N. Hong, Valentin Fuster, Robert S. Rosenson, Clive Rosendorff, Deepak L. Bhatt

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Diabetes, hyperlipidemia, and hypertension are modifiable risk factors that predict cardiovascular disease events. The effect of these risk factors on incident cardiovascular disease increases with progressively higher levels of glucose, low-density lipoprotein cholesterol, and blood pressure. The thresholds for initiating treatment of these modifiable risk factors and the optimal goals of risk factor modification are a focus of primary prevention research. Although an aggressive approach is appealing, adverse events may occur, and potential physiological barriers may exist. This paper discusses primary prevention of coronary heart disease that may be achieved through modification of diabetes, hyperlipidemia, and hypertension by summarizing current guidelines and pertinent clinical trial data from intervention trials that included a primary prevention cohort.

Original languageEnglish
Pages (from-to)2171-2185
Number of pages15
JournalJournal of the American College of Cardiology
Issue number17
StatePublished - 24 Oct 2017
Externally publishedYes


  • cardiovascular disease
  • diabetes
  • hyperlipidemia
  • hypertension
  • primary prevention


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