How does leptin restore euglycemia in insulin-deficient diabetes?

Douglas Oberlin, Christoph Buettner

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.

Original languageEnglish
Pages (from-to)450-453
Number of pages4
JournalJournal of Clinical Investigation
Issue number2
StatePublished - 1 Feb 2017


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