How cells know they are in G1 or G2

Matthew J. O'Connell; Paul Nurse

doi:10.1016/0955-0674(94)90058-2

How cells know they are in G₁ or G₂

Matthew J. O'Connell, Paul Nurse

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

How does a cell know if it's in G₁ or G₂ and should proceed to S phase or mitosis? This is a restatement of the question of how a cell ensures mitosis is dependent upon S phase, and S phase is dependent upon mitosis. Several gene products have been identified which play important roles in maintaining these interdependencies. Central to these controls are oscillations between different complexes of cyclins and cyclin-dependent kinases.

Original language	English
Pages (from-to)	867-871
Number of pages	5
Journal	Current Opinion in Cell Biology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0955-0674(94)90058-2
State	Published - Dec 1994
Externally published	Yes

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10.1016/0955-0674(94)90058-2

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title = "How cells know they are in G1 or G2",

abstract = "How does a cell know if it's in G1 or G2 and should proceed to S phase or mitosis? This is a restatement of the question of how a cell ensures mitosis is dependent upon S phase, and S phase is dependent upon mitosis. Several gene products have been identified which play important roles in maintaining these interdependencies. Central to these controls are oscillations between different complexes of cyclins and cyclin-dependent kinases.",

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AB - How does a cell know if it's in G1 or G2 and should proceed to S phase or mitosis? This is a restatement of the question of how a cell ensures mitosis is dependent upon S phase, and S phase is dependent upon mitosis. Several gene products have been identified which play important roles in maintaining these interdependencies. Central to these controls are oscillations between different complexes of cyclins and cyclin-dependent kinases.

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How cells know they are in G1 or G2

Abstract

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How cells know they are in G₁ or G₂