How a common variant in the growth factor receptor gene, NTRK1, affects white matter

Meredith N. Braskie, Neda Jahanshad, Arthur W. Toga, Katie L. McMahon, Greig I. de Zubicaray, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated in a number of mental illnesses. Recently, we reported that healthy young adults who carry the T allele variant in the growth factor gene, NTRK1 (at location rs6336), had lower white matter integrity than non-carriers on diffusion images of the brain. Diffusion tensor imaging (DTI) revealed how this single nucleotide polymorphism affects white matter microstructure in human populations; DTI is also used to identify characteristic features of brain connectivity in typically developing children and in patients. Newly discovered links between neuroimaging measures and growth factors whose molecular neuroscience is well known offer an important step in understanding mechanisms that contribute to brain connectivity. Altered fiber connectivity may mediate the relationship between some genetic risk factors and a variety of mental illnesses.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalBioarchitecture
Volume2
Issue number5
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Development
  • Diffusion tensor imaging
  • Fractional anisotropy
  • Growth factor
  • Myelin
  • Neurotrophic tyrosine kinase receptor 1
  • Neurotrophin
  • Radial diffusivity
  • Schizophrenia
  • Tropomyosin-related kinase receptor A

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