TY - JOUR
T1 - Host tissue determinants of tumour immunity
AU - Salmon, Hélène
AU - Remark, Romain
AU - Gnjatic, Sacha
AU - Merad, Miriam
N1 - Funding Information:
H.S. receives research funding from Takeda and Genentech. R.R. is an employee of Innate Pharma. S.G. reports consultancy and/or advisory roles for Merck, Neon Therapeutics and OncoMed and research funding from Bristol-Myers Squibb, Genentech, Immune Design, Agenus, Janssen R&D and Pfizer. M.M. receives funding from Regeneron, Takeda, Genentech and Boehringer Ingelheim.
Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.
AB - Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.
UR - http://www.scopus.com/inward/record.url?scp=85063013311&partnerID=8YFLogxK
U2 - 10.1038/s41568-019-0125-9
DO - 10.1038/s41568-019-0125-9
M3 - Review article
C2 - 30867580
AN - SCOPUS:85063013311
SN - 1474-175X
VL - 19
SP - 215
EP - 227
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 4
ER -