TY - JOUR
T1 - Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction
T2 - Results of the New York heart failure registry
AU - Klapholz, Marc
AU - Maurer, Matthew
AU - Lowe, April M.
AU - Messineo, Frank
AU - Meisner, Jay S.
AU - Mitchell, Judith
AU - Kalman, Jill
AU - Phillips, Robert A.
AU - Steingart, Richard
AU - Brown, Edward J.
AU - Berkowitz, Robert
AU - Moskowitz, Robert
AU - Soni, Anita
AU - Mancini, Donna
AU - Bijou, Rachel
AU - Sehhat, Khashayar
AU - Varshneya, Nikita
AU - Kukin, Marrick
AU - Katz, Stuart D.
AU - Sleeper, Lynn A.
AU - Le Jemtel, Thierry H.
PY - 2004/4/21
Y1 - 2004/4/21
N2 - Objectives We conducted a prospective multicenter registry in a large metropolitan area to define the clinical characteristics, hospital course, treatment, and factors precipitating decompensation in patients hospitalized for heart failure with a normal ejection fraction (HFNEF). Background The clinical profile of patients hospitalized for HFNEF has been characterized by retrospective analyses of hospital records and state data banks, with few prospective single-center studies. Methods Patients hospitalized for heart failure (HF) at 24 medical centers in the New York metropolitan area and found to have a left ventricular (LV) ejection fraction of ≥50% within seven days of admission were included in this registry. Patient demographics, signs and symptoms of HF, coexisting and exacerbating cardiovascular and medical conditions, treatment, laboratory tests, procedures, and hospital outcomes data were collected. Analysis by gender and race was prespecified. Results Of 619 patients, 73% were women, who were on average four years older than men (72.8 ± 14.1 years vs. 68.6 ± 13.8 years, p < 0.001). Black non-Hispanic patients comprised 30% of the study population. They were eight years younger than other patients (66.0 ± 14.2 years vs. 74 ± 13.5 years p < 0.001). Co-morbid conditions and their prevalence were: hypertension, 78%; increased LV mass, 82%; diabetes, 46%; and obesity, 46%. Before clinical decompensation that precipitated hospitalization, 86% of patients had chronic symptoms compatible with New York Heart Association functional classes II to IV. Factors precipitating clinical decompensation were identified in 53% of patients. In-hospital mortality was 4.2%. Conclusions Patients hospitalized for HFNEF are most often chronically incapacitated elderly women with a history of hypertension and increased LV mass. Reasons for clinical decompensation are identified in only one-half of patients.
AB - Objectives We conducted a prospective multicenter registry in a large metropolitan area to define the clinical characteristics, hospital course, treatment, and factors precipitating decompensation in patients hospitalized for heart failure with a normal ejection fraction (HFNEF). Background The clinical profile of patients hospitalized for HFNEF has been characterized by retrospective analyses of hospital records and state data banks, with few prospective single-center studies. Methods Patients hospitalized for heart failure (HF) at 24 medical centers in the New York metropolitan area and found to have a left ventricular (LV) ejection fraction of ≥50% within seven days of admission were included in this registry. Patient demographics, signs and symptoms of HF, coexisting and exacerbating cardiovascular and medical conditions, treatment, laboratory tests, procedures, and hospital outcomes data were collected. Analysis by gender and race was prespecified. Results Of 619 patients, 73% were women, who were on average four years older than men (72.8 ± 14.1 years vs. 68.6 ± 13.8 years, p < 0.001). Black non-Hispanic patients comprised 30% of the study population. They were eight years younger than other patients (66.0 ± 14.2 years vs. 74 ± 13.5 years p < 0.001). Co-morbid conditions and their prevalence were: hypertension, 78%; increased LV mass, 82%; diabetes, 46%; and obesity, 46%. Before clinical decompensation that precipitated hospitalization, 86% of patients had chronic symptoms compatible with New York Heart Association functional classes II to IV. Factors precipitating clinical decompensation were identified in 53% of patients. In-hospital mortality was 4.2%. Conclusions Patients hospitalized for HFNEF are most often chronically incapacitated elderly women with a history of hypertension and increased LV mass. Reasons for clinical decompensation are identified in only one-half of patients.
KW - B-NH
KW - BP
KW - Black non-Hispanic
KW - Blood pressure
KW - EF
KW - Ejection fraction
KW - GFR
KW - Glomerular filtration rate
KW - HF
KW - HFNEF
KW - Heart failure
KW - Heart failure with normal ejection fraction
KW - LV
KW - Left ventricle/ventricular
UR - http://www.scopus.com/inward/record.url?scp=11144354091&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2003.11.040
DO - 10.1016/j.jacc.2003.11.040
M3 - Article
C2 - 15093880
AN - SCOPUS:11144354091
SN - 0735-1097
VL - 43
SP - 1432
EP - 1438
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 8
ER -