Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit

Claudette L. Poole; Bernard C. Camins; Mark N. Prichard; Ona Faye-Petersen; Cecelia Hutto

doi:10.1038/s41372-019-0318-9

Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit

Claudette L. Poole, Bernard C. Camins, Mark N. Prichard, Ona Faye-Petersen, Cecelia Hutto

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objective: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. Study design: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. Results: Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p = 0.048); were hospitalized longer (97 d vs 43 d, p = 0.013); required more antibiotics (8 d vs. 4 d, p = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia (p = 0.008) compared to VRI negative infants. Conclusion: Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes.

Original language	English
Pages (from-to)	683-689
Number of pages	7
Journal	Journal of Perinatology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1038/s41372-019-0318-9
State	Published - 1 May 2019
Externally published	Yes

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title = "Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit",

abstract = "Objective: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. Study design: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. Results: Seventy-four infants enrolled, with 5 (6.8\%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p = 0.048); were hospitalized longer (97 d vs 43 d, p = 0.013); required more antibiotics (8 d vs. 4 d, p = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia (p = 0.008) compared to VRI negative infants. Conclusion: Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes.",

author = "Poole, \{Claudette L.\} and Camins, \{Bernard C.\} and Prichard, \{Mark N.\} and Ona Faye-Petersen and Cecelia Hutto",

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AU - Poole, Claudette L.

AU - Camins, Bernard C.

AU - Prichard, Mark N.

AU - Faye-Petersen, Ona

AU - Hutto, Cecelia

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objective: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. Study design: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. Results: Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p = 0.048); were hospitalized longer (97 d vs 43 d, p = 0.013); required more antibiotics (8 d vs. 4 d, p = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia (p = 0.008) compared to VRI negative infants. Conclusion: Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes.

AB - Objective: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. Study design: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. Results: Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p = 0.048); were hospitalized longer (97 d vs 43 d, p = 0.013); required more antibiotics (8 d vs. 4 d, p = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia (p = 0.008) compared to VRI negative infants. Conclusion: Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes.

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Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit

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