TY - CHAP
T1 - Hormone therapy effects on the uterus
AU - Deligdisch-Schor, Liane
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2020.
PY - 2020
Y1 - 2020
N2 - The uterus and especially the endometrium are sensitive targets for steroid sex hormones, capable to modify structure and function with promptitude and versatility in order to secure reproductive functions. Hormone therapy is used to counteract deprivation, abnormal, and deleterious functions of “natural” hormones. It is widely prescribed, being used by millions of women all over the world. It seems that most women would use at least some hormone therapy at some point of their life, as contraceptives, ovarian stimulation, replacement therapy, or hormone antitumoral therapy. The diagnosis of uterine tissue, mostly of the frequently performed endometrial biopsies taken from women undergoing hormone therapy, is often confusing and difficult to interpret due to the complexity of histologic changes. Permanently changing hormonal pharmaceutical products, regimens, dosages, as well as new concepts of therapy are challenges for both users and medical prescribers. This chapter addresses the most commonly issues arising from the gynecological pathology interpretation of hormonal therapy effects on the uterus.
AB - The uterus and especially the endometrium are sensitive targets for steroid sex hormones, capable to modify structure and function with promptitude and versatility in order to secure reproductive functions. Hormone therapy is used to counteract deprivation, abnormal, and deleterious functions of “natural” hormones. It is widely prescribed, being used by millions of women all over the world. It seems that most women would use at least some hormone therapy at some point of their life, as contraceptives, ovarian stimulation, replacement therapy, or hormone antitumoral therapy. The diagnosis of uterine tissue, mostly of the frequently performed endometrial biopsies taken from women undergoing hormone therapy, is often confusing and difficult to interpret due to the complexity of histologic changes. Permanently changing hormonal pharmaceutical products, regimens, dosages, as well as new concepts of therapy are challenges for both users and medical prescribers. This chapter addresses the most commonly issues arising from the gynecological pathology interpretation of hormonal therapy effects on the uterus.
KW - Contraceptives
KW - Endometrial cancer
KW - Endometrium
KW - Estrogens
KW - Hormone receptors
KW - Hormone therapy
KW - Menopause
KW - Progesterone
KW - Steroid sex hormones
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=85084627007&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-38474-6_8
DO - 10.1007/978-3-030-38474-6_8
M3 - Chapter
C2 - 32406032
AN - SCOPUS:85084627007
T3 - Advances in Experimental Medicine and Biology
SP - 145
EP - 177
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -