Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment

Emil F. Coccaro; Richard J. Kavoussi; Robert L. Trestman; Steven M. Gabriel; Thomas B. Cooper; Larry J. Siever

doi:10.1016/0165-1781(96)02826-0

Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment

Emil F. Coccaro, Richard J. Kavoussi, Robert L. Trestman, Steven M. Gabriel, Thomas B. Cooper, Larry J. Siever

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days, Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.

Original language	English
Pages (from-to)	139-145
Number of pages	7
Journal	Psychiatry Research
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(96)02826-0
State	Published - 17 May 1996

Keywords

Cortisol
Prolactin
Serotonin

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title = "Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment",

abstract = "Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days, Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.",

keywords = "Cortisol, Prolactin, Serotonin",

author = "Coccaro, {Emil F.} and Kavoussi, {Richard J.} and Trestman, {Robert L.} and Gabriel, {Steven M.} and Cooper, {Thomas B.} and Siever, {Larry J.}",

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T1 - Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment

AU - Coccaro, Emil F.

AU - Kavoussi, Richard J.

AU - Trestman, Robert L.

AU - Gabriel, Steven M.

AU - Cooper, Thomas B.

AU - Siever, Larry J.

PY - 1996/5/17

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N2 - Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days, Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.

AB - Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days, Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.

KW - Cortisol

KW - Prolactin

KW - Serotonin

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ER -

Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment

Abstract

Keywords

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