Hormonal control of plasma renin substrate (angiotensinogen)

L. R. Krakoff; A. J. Eisenfeld

doi:10.1161/01.res.41.4.43

Hormonal control of plasma renin substrate (angiotensinogen)

L. R. Krakoff
, A. J. Eisenfeld

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The effect of ethinyl estradiol (EE₂) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Normal adult rats had large increases in PRS when given either EE₂ or Dex. Prepubescent (25-day-old) rats also had a substantial increase in PRS following Dex, but no increase in PRS after EE₂. In adult rats, hypophysectomy prevented the rise in PRS due to EE₂ but did not prevent the increase in PRS due to Dex. Hepatic estrogen and glucocorticoid receptors were measured in immature and adult rats. Immature rats had markedly reduced concentration of hepatic estrogen receptors (16%), compared with adults. In contrast, glucocorticoid receptor concentration was not significantly different between immature and adult rats. The results indicate that the effect of estrogens and glucocorticoids upon PRS are mediated by pathways that are separable at the hormone receptor level.

Original language	English
Pages (from-to)	II-43-II-46
Journal	Circulation Research
Volume	41
Issue number	4 suppl. 2
DOIs	https://doi.org/10.1161/01.res.41.4.43
State	Published - 1977
Externally published	Yes

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title = "Hormonal control of plasma renin substrate (angiotensinogen)",

abstract = "The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Normal adult rats had large increases in PRS when given either EE2 or Dex. Prepubescent (25-day-old) rats also had a substantial increase in PRS following Dex, but no increase in PRS after EE2. In adult rats, hypophysectomy prevented the rise in PRS due to EE2 but did not prevent the increase in PRS due to Dex. Hepatic estrogen and glucocorticoid receptors were measured in immature and adult rats. Immature rats had markedly reduced concentration of hepatic estrogen receptors (16\%), compared with adults. In contrast, glucocorticoid receptor concentration was not significantly different between immature and adult rats. The results indicate that the effect of estrogens and glucocorticoids upon PRS are mediated by pathways that are separable at the hormone receptor level.",

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language = "English",

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TY - JOUR

T1 - Hormonal control of plasma renin substrate (angiotensinogen)

AU - Krakoff, L. R.

AU - Eisenfeld, A. J.

PY - 1977

Y1 - 1977

N2 - The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Normal adult rats had large increases in PRS when given either EE2 or Dex. Prepubescent (25-day-old) rats also had a substantial increase in PRS following Dex, but no increase in PRS after EE2. In adult rats, hypophysectomy prevented the rise in PRS due to EE2 but did not prevent the increase in PRS due to Dex. Hepatic estrogen and glucocorticoid receptors were measured in immature and adult rats. Immature rats had markedly reduced concentration of hepatic estrogen receptors (16%), compared with adults. In contrast, glucocorticoid receptor concentration was not significantly different between immature and adult rats. The results indicate that the effect of estrogens and glucocorticoids upon PRS are mediated by pathways that are separable at the hormone receptor level.

AB - The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Normal adult rats had large increases in PRS when given either EE2 or Dex. Prepubescent (25-day-old) rats also had a substantial increase in PRS following Dex, but no increase in PRS after EE2. In adult rats, hypophysectomy prevented the rise in PRS due to EE2 but did not prevent the increase in PRS due to Dex. Hepatic estrogen and glucocorticoid receptors were measured in immature and adult rats. Immature rats had markedly reduced concentration of hepatic estrogen receptors (16%), compared with adults. In contrast, glucocorticoid receptor concentration was not significantly different between immature and adult rats. The results indicate that the effect of estrogens and glucocorticoids upon PRS are mediated by pathways that are separable at the hormone receptor level.

UR - https://www.scopus.com/pages/publications/0017611465

U2 - 10.1161/01.res.41.4.43

DO - 10.1161/01.res.41.4.43

M3 - Article

C2 - 902371

AN - SCOPUS:0017611465

SN - 0009-7330

VL - 41

SP - II-43-II-46

JO - Circulation Research

JF - Circulation Research

IS - 4 suppl. 2

ER -

Hormonal control of plasma renin substrate (angiotensinogen)

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