Hormonal and metabolic effects of angiotensin converting enzyme inhibitors. Possible differences between enalapril and captopril

S. A. Atlas, D. B. Case, Yuan Yu Zhung Yuan Yu, J. H. Laragh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Inhibitors of angiotensin converting enzyme block the conversion of angiotensin I to angiotensin II, the active hormone of the renin-angiotensin system. This inhibition leads to a reduction in angiotensin-mediated vasoconstriction and aldosterone production. Although converting enzyme inhibitors have other potential metabolic effects, their beneficial effects in hypertension and congestive heart failure appear to be, in large part, related to their ability to reduce angiotensin II. This causes an increase in plasma renin levels and a fall in plasma and urine aldosterone, which can be sustained for many years. As a consequence, converting enzyme inhibitors produce mild natriuresis and positive potassium balance. At conventionally used doses, enalapril more completely prevents posture-induced increases in aldosterone than does captopril, probably reflecting more complete inhibition of angiotensin II formation in vivo.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalAmerican Journal of Medicine
Volume77
Issue number2 A
DOIs
StatePublished - 1984
Externally publishedYes

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