Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

H. Ueno; N. Kaniwa; T. Okusaka; M. Ikeda; C. Morizane; S. Kondo; E. Sugiyama; S. R. Kim; R. Hasegawa; Y. Saito; T. Yoshida; N. Saijo; J. Sawada

doi:10.1038/sj.bjc.6604971

Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

H. Ueno
, N. Kaniwa
, T. Okusaka
, M. Ikeda
, C. Morizane
, S. Kondo
, E. Sugiyama
, S. R. Kim
, R. Hasegawa
, Y. Saito
, T. Yoshida
, N. Saijo
, J. Sawada

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A[Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population.

Original language	English
Pages (from-to)	870-873
Number of pages	4
Journal	British Journal of Cancer
Volume	100
Issue number	6
DOIs	https://doi.org/10.1038/sj.bjc.6604971
State	Published - 24 Mar 2009
Externally published	Yes

Keywords

CDA208G>A
Gemcitabine
Pharmacogenomics
Polymorphism
Toxicity
pancreatic cancer

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title = "Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients",

abstract = "Among 242 Japanese pancreatic cancer patients, three patients (1.2\%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A[Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population.",

keywords = "CDA208G>A, Gemcitabine, Pharmacogenomics, Polymorphism, Toxicity, pancreatic cancer",

author = "H. Ueno and N. Kaniwa and T. Okusaka and M. Ikeda and C. Morizane and S. Kondo and E. Sugiyama and Kim, \{S. R.\} and R. Hasegawa and Y. Saito and T. Yoshida and N. Saijo and J. Sawada",

year = "2009",

month = mar,

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doi = "10.1038/sj.bjc.6604971",

language = "English",

volume = "100",

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journal = "British Journal of Cancer",

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TY - JOUR

T1 - Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

AU - Ueno, H.

AU - Kaniwa, N.

AU - Okusaka, T.

AU - Ikeda, M.

AU - Morizane, C.

AU - Kondo, S.

AU - Sugiyama, E.

AU - Kim, S. R.

AU - Hasegawa, R.

AU - Saito, Y.

AU - Yoshida, T.

AU - Saijo, N.

AU - Sawada, J.

PY - 2009/3/24

Y1 - 2009/3/24

N2 - Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A[Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population.

AB - Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A[Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population.

KW - CDA208G>A

KW - Gemcitabine

KW - Pharmacogenomics

KW - Polymorphism

KW - Toxicity

KW - pancreatic cancer

UR - https://www.scopus.com/pages/publications/62549146215

U2 - 10.1038/sj.bjc.6604971

DO - 10.1038/sj.bjc.6604971

M3 - Article

C2 - 19293806

AN - SCOPUS:62549146215

SN - 0007-0920

VL - 100

SP - 870

EP - 873

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

Abstract

Keywords

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