Homotypic regulatory cluster in Drosophila

Alexander P. Lifanov, Vsevolod J. Makeev, Anna G. Nazina, Dmitri A. Papatsenko

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Cis-regulatory modules (CRMs) are transcription regulatory DNA segments (-1 Kb range) that control the expression of developmental genes in higher eukaryotes. We analyzed clustering of known binding motifs for transcription factors (TFs) in over 60 known CRMs from 20 Drosophila developmental genes, and we present evidence that each type of recognition motif forms significant clusters within the regulatory regions regulated by the corresponding TF. We demonstrate how a search with a single binding motif can be applied to explore gene regulatory networks and to discover coregulated genes in the genome. We also discuss the potential of the clustering method in interpreting the differential response of genes to various levels of transcriptional regulators.

Original languageEnglish
Pages (from-to)579-588
Number of pages10
JournalGenome Research
Volume13
Issue number4
DOIs
StatePublished - 1 Apr 2003
Externally publishedYes

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