Abstract
Immunoevasive viruses which effect antigen presentation by class I major histocompatibility complex (MHC) molecules have helped to broaden our understanding of the intracellular transport and processing of HLA-G and HLA-C in the placenta. Cellular infection with herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are each associated with the downregulation of surface expression of HLA-A and -B, albeit by remarkably distinct mechanisms. Investigations on the effects of HSV and HCMV infection on HLA-G and HLA-C in the trophoblast have revealed both hypothesized similarities and surprising differences between trophoblast and classical class I products.
Original language | English |
---|---|
Pages (from-to) | 37-46 |
Number of pages | 10 |
Journal | Seminars in Cancer Biology |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1999 |
Keywords
- Antigen presentation
- HLA-G
- Immunoevasion
- Trophoblast
- Virus