HLA-G and HLA-C at the feto-maternal interface: Lessons learned from pathogenic viruses

Danny J. Schust, Domenico Tortorella, Hidde L. Ploegh

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Immunoevasive viruses which effect antigen presentation by class I major histocompatibility complex (MHC) molecules have helped to broaden our understanding of the intracellular transport and processing of HLA-G and HLA-C in the placenta. Cellular infection with herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are each associated with the downregulation of surface expression of HLA-A and -B, albeit by remarkably distinct mechanisms. Investigations on the effects of HSV and HCMV infection on HLA-G and HLA-C in the trophoblast have revealed both hypothesized similarities and surprising differences between trophoblast and classical class I products.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalSeminars in Cancer Biology
Volume9
Issue number1
DOIs
StatePublished - Feb 1999

Keywords

  • Antigen presentation
  • HLA-G
  • Immunoevasion
  • Trophoblast
  • Virus

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