TY - JOUR
T1 - HLA-DS molecules and their relation to supertypic specificities
AU - Goyert, Sanna M.
AU - Moriuchi, Junko
AU - Winchester, Robert
AU - Silver, Jack
N1 - Funding Information:
*Supported by grants from NIAID. N1H. the Kroc Foundation. and the National Multiple Sclerosis Society. From the Department of Microbiology and Public Health. Michigan State Unit~ersity. East Lansing. MI: and the Hospital for Joint Diseases Orthopaedic Institute, Mount Sinai School of Medicine. New York. NY. Address requests for reprints to Dr. Robert Winchester. The Erwin S. and Rose F. Wolfsen Laboralor3 of Cellular Mechanisms of Disease. The Hospital for Joint Diseases Orthopaedic Institute. Mount Sinai School of Medicine, New York, NY 10003. Received April 26. 1983: accepted April 27. 1983.
PY - 1983/9
Y1 - 1983/9
N2 - We have analyzed the structures of HLA-DS molecules from DR1, 2, 3, 4, 5, and 7 cell lines by two-dimensional gel electrophoresis and examined the relationship of HLA-DS molecules to those expressing the supertypic specificities MT1, MB3, and MT3. These studies have allowed us to conclude that the HLA-DS locus is as polymorphic as HLA-DR and that the MT1 and MB3 supertypic specificities reside on DS molecules. Furthermore, MT1 molecules from DR1, DR2, and DRw6 cell lines are structurally different as are MB3 molecules from DR4 and DR5 cell lines. In addition, studies using two MT3 specific reagents, a monoclonal antibody, 109d6, and an alloantiserum, Hon, suggest that MT3 is a cross-reactive determinant present on products of two different loci: a DS4 molecule and a DR7-like molecule.
AB - We have analyzed the structures of HLA-DS molecules from DR1, 2, 3, 4, 5, and 7 cell lines by two-dimensional gel electrophoresis and examined the relationship of HLA-DS molecules to those expressing the supertypic specificities MT1, MB3, and MT3. These studies have allowed us to conclude that the HLA-DS locus is as polymorphic as HLA-DR and that the MT1 and MB3 supertypic specificities reside on DS molecules. Furthermore, MT1 molecules from DR1, DR2, and DRw6 cell lines are structurally different as are MB3 molecules from DR4 and DR5 cell lines. In addition, studies using two MT3 specific reagents, a monoclonal antibody, 109d6, and an alloantiserum, Hon, suggest that MT3 is a cross-reactive determinant present on products of two different loci: a DS4 molecule and a DR7-like molecule.
UR - http://www.scopus.com/inward/record.url?scp=0021066869&partnerID=8YFLogxK
U2 - 10.1016/0198-8859(83)90082-4
DO - 10.1016/0198-8859(83)90082-4
M3 - Article
C2 - 6195135
AN - SCOPUS:0021066869
SN - 0198-8859
VL - 8
SP - 53
EP - 63
JO - Human Immunology
JF - Human Immunology
IS - 1
ER -