HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13

Francesco Indiveri; Carlo Russo; Vito Quaranta; Michele A. Pellegrino; Soldano Ferrone

doi:10.1016/0008-8749(81)90341-5

HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13

Francesco Indiveri, Carlo Russo, Vito Quaranta, Michele A. Pellegrino, Soldano Ferrone

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Human T lymphocytes release factors which enhance the mitogenic response of B lymphocytes to PWM. These mitogenic factors share with HLA-DR antigens the framework determinant recognized by the monoclonal antibody Q5/13 (MoAb Q5/13) since adsorption of T-cell medium with an excess of insolubilized MoAb Q5/13 significantly reduces the enhancing activity of the T-cell supernatant on the proliferative response of B cells to PWM. On the other hand, incubation of the T-cell supernatant with an excess of insolubilized anti-HLA-A,B MoAb Q1/28 did not effect the activity of the T-cell supernatant in the proliferative assay.

Original language	English
Pages (from-to)	406-411
Number of pages	6
Journal	Cellular Immunology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(81)90341-5
State	Published - Aug 1981
Externally published	Yes

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@article{3b063aa767264e5180ccc3d548119592,

title = "HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13",

abstract = "Human T lymphocytes release factors which enhance the mitogenic response of B lymphocytes to PWM. These mitogenic factors share with HLA-DR antigens the framework determinant recognized by the monoclonal antibody Q5/13 (MoAb Q5/13) since adsorption of T-cell medium with an excess of insolubilized MoAb Q5/13 significantly reduces the enhancing activity of the T-cell supernatant on the proliferative response of B cells to PWM. On the other hand, incubation of the T-cell supernatant with an excess of insolubilized anti-HLA-A,B MoAb Q1/28 did not effect the activity of the T-cell supernatant in the proliferative assay.",

author = "Francesco Indiveri and Carlo Russo and Vito Quaranta and Pellegrino, {Michele A.} and Soldano Ferrone",

note = "Funding Information: {\textquoteright} This work was supported by the National Institutes of Health Grants AI 13154, CA 16069, CA 16071, and CA 24329, a Research Career Development Award (M.A.P.), and an American Heart Association Established Investigatorship Award (SF.). This is Publication No. 2504 from Scripps Clinic and Research Foundation.",

year = "1981",

month = aug,

doi = "10.1016/0008-8749(81)90341-5",

language = "English",

volume = "62",

pages = "406--411",

journal = "Cellular Immunology",

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publisher = "Academic Press Inc.",

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T1 - HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13

AU - Indiveri, Francesco

AU - Russo, Carlo

AU - Quaranta, Vito

AU - Pellegrino, Michele A.

AU - Ferrone, Soldano

N1 - Funding Information: ’ This work was supported by the National Institutes of Health Grants AI 13154, CA 16069, CA 16071, and CA 24329, a Research Career Development Award (M.A.P.), and an American Heart Association Established Investigatorship Award (SF.). This is Publication No. 2504 from Scripps Clinic and Research Foundation.

PY - 1981/8

Y1 - 1981/8

N2 - Human T lymphocytes release factors which enhance the mitogenic response of B lymphocytes to PWM. These mitogenic factors share with HLA-DR antigens the framework determinant recognized by the monoclonal antibody Q5/13 (MoAb Q5/13) since adsorption of T-cell medium with an excess of insolubilized MoAb Q5/13 significantly reduces the enhancing activity of the T-cell supernatant on the proliferative response of B cells to PWM. On the other hand, incubation of the T-cell supernatant with an excess of insolubilized anti-HLA-A,B MoAb Q1/28 did not effect the activity of the T-cell supernatant in the proliferative assay.

AB - Human T lymphocytes release factors which enhance the mitogenic response of B lymphocytes to PWM. These mitogenic factors share with HLA-DR antigens the framework determinant recognized by the monoclonal antibody Q5/13 (MoAb Q5/13) since adsorption of T-cell medium with an excess of insolubilized MoAb Q5/13 significantly reduces the enhancing activity of the T-cell supernatant on the proliferative response of B cells to PWM. On the other hand, incubation of the T-cell supernatant with an excess of insolubilized anti-HLA-A,B MoAb Q1/28 did not effect the activity of the T-cell supernatant in the proliferative assay.

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HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13

Abstract

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