HLA-DQA1 and polymarker allele frequencies in two New York City Jewish populations

Igor Medintz, Louis Levine, Leslie McCurdy, Luis Chiriboga, Charles Kingston, Robert J. Desnick, Christine M. Eng, L. Kobilinsky

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Allele and genotype frequencies were determined for the HLA-DQA1 and Amplitype® Polymarker loci (low density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8, and group- specific component (Gc)) in Hasidic and non-Hasidic Ashkenazi New York City Jewish subpopulations. For all loci tested, except HBGG, the 2 subpopulations meet the assumption of Hardy-Weinberg equilibrium. Comparison of various allele and genotype frequencies for the Hasidic and the non-Hasidic groups showed no significant differences. Comparison of the various allele frequencies in the two subpopulations to another Caucasian group revealed significant differences at the HLA-DQA1 and D7S8 loci in the Hasidic group. These frequency data can be used for comparison to other populations and for frequency estimates in DNA profiling.

Original languageEnglish
Pages (from-to)919-922
Number of pages4
JournalJournal of Forensic Sciences
Issue number5
StatePublished - Sep 1997
Externally publishedYes


  • Allele frequencies
  • D7S8
  • DNA typing
  • Forensic science
  • GC
  • GYPA
  • HBGG
  • HLA- DQA1
  • Jewish populations
  • LDLR
  • New York City
  • Polymarker
  • Polymerase chain reaction
  • Population genetics


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