HL-A Antigens of Human Tumor-Derived Cell Lines and Viral Transformed Fibroblasts in Culture

John H. Kersey; Edmond J. Yunis; George J. Todaro; Stuart A. Aaronson

doi:10.3181/00379727-143-37341

HL-A Antigens of Human Tumor-Derived Cell Lines and Viral Transformed Fibroblasts in Culture

John H. Kersey, Edmond J. Yunis, George J. Todaro, Stuart A. Aaronson

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Abstract

Histocompatibility (HL-A) antigens were demonstrated on 95% of 217 cultured adult human fibroblast strains using a microcytoxicity method. Four of eight lines established from human tumors showed no HL-A reactivity. By contrast, no loss of HL-A reactivity was found in fibroblast strains transformed in vitro by simian virus 40 (SV40) or murine sarcoma virus (Kirsten strain).

Original language	English
Pages (from-to)	453-456
Number of pages	4
Journal	Experimental Biology and Medicine
Volume	143
Issue number	2
DOIs	https://doi.org/10.3181/00379727-143-37341
State	Published - Jun 1973
Externally published	Yes

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abstract = "Histocompatibility (HL-A) antigens were demonstrated on 95% of 217 cultured adult human fibroblast strains using a microcytoxicity method. Four of eight lines established from human tumors showed no HL-A reactivity. By contrast, no loss of HL-A reactivity was found in fibroblast strains transformed in vitro by simian virus 40 (SV40) or murine sarcoma virus (Kirsten strain).",

author = "Kersey, {John H.} and Yunis, {Edmond J.} and Todaro, {George J.} and Aaronson, {Stuart A.}",

note = "Funding Information: Supported in part by NIH Contracts PH 70-2047 and 71-2261. 6 1973 143 2 453 456 ",

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AU - Aaronson, Stuart A.

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AB - Histocompatibility (HL-A) antigens were demonstrated on 95% of 217 cultured adult human fibroblast strains using a microcytoxicity method. Four of eight lines established from human tumors showed no HL-A reactivity. By contrast, no loss of HL-A reactivity was found in fibroblast strains transformed in vitro by simian virus 40 (SV40) or murine sarcoma virus (Kirsten strain).

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HL-A Antigens of Human Tumor-Derived Cell Lines and Viral Transformed Fibroblasts in Culture

Abstract

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