HIV infection and critical illness: Pulmonary in origin

Mangala Narasimhan, Mark J. Rosen

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite the effectiveness of HAART and prophylaxis against opportunistic infections, Pneumocystis carinii pneumonia (PCP) is still the most common reason for ICU admission of HIV-infected patients. Bronchoscopy with bronchoalveolar lavage, with or without biopsy, or sputum induction with hypertonic saline is used to establish the diagnosis. The predictive value of various laboratory tests and scoring systems in determining outcomes varies for patients with PCP. The severity of the underlying HIV disorder or comorbid disease, and the experience of the hospital and caregivers appear to have the most bearing on clinical outcomes. Decisions regarding the appropriateness of critical care for patients, regardless of whether they are currently being treated with HAART, may require close collaboration with an expert in antiretroviral treatment.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalJournal of Critical Illness
Volume17
Issue number8
StatePublished - Aug 2002
Externally publishedYes

Keywords

  • Clinical Conclusions
  • Outcome predictors
  • Pathologic profile
  • Prognostic prospects
  • Radiographic clues
  • Treatment options and dosage regimens

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