HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection

Lidia Ruiz, Guislaine Carcelain, Javier Martínez-Picado, Simon Frost, Silvia Marfil, Roger Paredes, Joan Romeu, Esther Ferrer, Kristina Morales-Lopetegi, Brigitte Autran, Bonaventura Clotet

Research output: Contribution to journalArticlepeer-review

138 Scopus citations


Objective: To evaluate whether controlled re-exposures to autologous HIV-1 could boost HIV-specific immunity and limit virus replication in patients with chronic HIV-1 infection. Patients and design: Subjects with at least 2 years virus suppression during antiretroviral therapy and a CD4: CD8 ratio > 1 were randomly assigned to interrupt highly active antiretroviral treatment (HAART) three times (n = 12) or to continue their previous HAART (n = 14). Results: In 10/12 interrupter patients a rebound of HIV-1 RNA was detected in all three structured treatment interruptions (STI). Plasma virus doubling time was shorter during the first STI than in the second and third STI, corresponding to an average 13% reduction in viral basic reproductive rate. However, the mean time before plasma viral load rose to > 50 copies/ml was significantly shorter in the second and third STI. The average frequency of HIV-specific CD8 T cells in the interrupter patients at the end of the third STI cycle was significantly higher compared with the baseline and the end of the first STI. A substantial increase in HIV-specific CD8 T cell frequencies was found in four interrupter patients, whereas there were no changes in all 14 non-interrupter individuals. A weak p24-specific T helper response developed in 5/12 interrupter patients compared with no response in non-interruptors, but these responses were transient and disappeared rapidly. Conclusion: The increase in the control of viral replication, and positive effects of STI on immune responses in this population should encourage the further development of HIV-specific immune-based therapeutic strategies.

Original languageEnglish
Pages (from-to)F19-F27
Issue number9
StatePublished - 15 Jun 2001
Externally publishedYes


  • Chronic HIV infection
  • HIV dynamics
  • HIV-specific T cell response
  • Structured treatment interruption


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