HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti; F. Canducci; L. Galli; F. Cossarini; S. Salpietro; A. Poli; S. Nozza; V. Spagnuolo; M. Clementi; M. Sampaolo; E. R. Ceresola; S. Racca; A. Lazzarin; A. Castagna

doi:10.1016/j.cmi.2014.08.004

HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti
, F. Canducci
, L. Galli
, F. Cossarini
, S. Salpietro
, A. Poli
, S. Nozza
, V. Spagnuolo
, M. Clementi
, M. Sampaolo
, E. R. Ceresola
, S. Racca
, A. Lazzarin
, A. Castagna

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/10⁶ peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

Original language	English
Pages (from-to)	103.e7-103.e10
Journal	Clinical Microbiology and Infection
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.cmi.2014.08.004
State	Published - 2015
Externally published	Yes

Keywords

HIV-1 DNA load
KPCR
Residual viraemia
Virological failure
Virological rebound

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10.1016/j.cmi.2014.08.004

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Gianotti, N., Canducci, F., Galli, L., Cossarini, F., Salpietro, S., Poli, A., Nozza, S., Spagnuolo, V., Clementi, M., Sampaolo, M., Ceresola, E. R., Racca, S., Lazzarin, A., & Castagna, A. (2015). HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. Clinical Microbiology and Infection, 21(1), 103.e7-103.e10. https://doi.org/10.1016/j.cmi.2014.08.004

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title = "HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients",

abstract = "In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54\%) subjects had undetectable HIV RNA and 90 (46\%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15\%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.",

keywords = "HIV-1 DNA load, KPCR, Residual viraemia, Virological failure, Virological rebound",

author = "N. Gianotti and F. Canducci and L. Galli and F. Cossarini and S. Salpietro and A. Poli and S. Nozza and V. Spagnuolo and M. Clementi and M. Sampaolo and Ceresola, \{E. R.\} and S. Racca and A. Lazzarin and A. Castagna",

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doi = "10.1016/j.cmi.2014.08.004",

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Gianotti, N, Canducci, F, Galli, L, Cossarini, F, Salpietro, S, Poli, A, Nozza, S, Spagnuolo, V, Clementi, M, Sampaolo, M, Ceresola, ER, Racca, S, Lazzarin, A & Castagna, A 2015, 'HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients', Clinical Microbiology and Infection, vol. 21, no. 1, pp. 103.e7-103.e10. https://doi.org/10.1016/j.cmi.2014.08.004

TY - JOUR

T1 - HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

AU - Gianotti, N.

AU - Canducci, F.

AU - Galli, L.

AU - Cossarini, F.

AU - Salpietro, S.

AU - Poli, A.

AU - Nozza, S.

AU - Spagnuolo, V.

AU - Clementi, M.

AU - Sampaolo, M.

AU - Ceresola, E. R.

AU - Racca, S.

AU - Lazzarin, A.

AU - Castagna, A.

PY - 2015

Y1 - 2015

N2 - In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

AB - In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

KW - HIV-1 DNA load

KW - KPCR

KW - Residual viraemia

KW - Virological failure

KW - Virological rebound

UR - https://www.scopus.com/pages/publications/84926288041

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DO - 10.1016/j.cmi.2014.08.004

M3 - Article

C2 - 25636935

AN - SCOPUS:84926288041

SN - 1198-743X

VL - 21

SP - 103.e7-103.e10

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 1

ER -

HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

Abstract

Keywords

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