HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti; F. Canducci; L. Galli; F. Cossarini; S. Salpietro; A. Poli; S. Nozza; V. Spagnuolo; M. Clementi; M. Sampaolo; E. R. Ceresola; S. Racca; A. Lazzarin; A. Castagna

doi:10.1016/j.cmi.2014.08.004

HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti, F. Canducci, L. Galli, F. Cossarini, S. Salpietro, A. Poli, S. Nozza, V. Spagnuolo, M. Clementi, M. Sampaolo, E. R. Ceresola, S. Racca, A. Lazzarin, A. Castagna

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/10⁶ peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

Original language	English
Pages (from-to)	103.e7-103.e10
Journal	Clinical Microbiology and Infection
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.cmi.2014.08.004
State	Published - 2015
Externally published	Yes

Keywords

HIV-1 DNA load
KPCR
Residual viraemia
Virological failure
Virological rebound

Access to Document

10.1016/j.cmi.2014.08.004

Cite this

Gianotti, N., Canducci, F., Galli, L., Cossarini, F., Salpietro, S., Poli, A., Nozza, S., Spagnuolo, V., Clementi, M., Sampaolo, M., Ceresola, E. R., Racca, S., Lazzarin, A., & Castagna, A. (2015). HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. Clinical Microbiology and Infection, 21(1), 103.e7-103.e10. https://doi.org/10.1016/j.cmi.2014.08.004

@article{be7d93f7a7d94cde9d865a35e43233fb,

title = "HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients",

abstract = "In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.",

keywords = "HIV-1 DNA load, KPCR, Residual viraemia, Virological failure, Virological rebound",

author = "N. Gianotti and F. Canducci and L. Galli and F. Cossarini and S. Salpietro and A. Poli and S. Nozza and V. Spagnuolo and M. Clementi and M. Sampaolo and Ceresola, {E. R.} and S. Racca and A. Lazzarin and A. Castagna",

note = "Publisher Copyright: {\textcopyright} 2014 European Society of Clinical Microbiology and Infectious Diseases.",

year = "2015",

doi = "10.1016/j.cmi.2014.08.004",

language = "English",

volume = "21",

pages = "103.e7--103.e10",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier B.V.",

number = "1",

}

Gianotti, N, Canducci, F, Galli, L, Cossarini, F, Salpietro, S, Poli, A, Nozza, S, Spagnuolo, V, Clementi, M, Sampaolo, M, Ceresola, ER, Racca, S, Lazzarin, A & Castagna, A 2015, 'HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients', Clinical Microbiology and Infection, vol. 21, no. 1, pp. 103.e7-103.e10. https://doi.org/10.1016/j.cmi.2014.08.004

TY - JOUR

T1 - HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

AU - Gianotti, N.

AU - Canducci, F.

AU - Galli, L.

AU - Cossarini, F.

AU - Salpietro, S.

AU - Poli, A.

AU - Nozza, S.

AU - Spagnuolo, V.

AU - Clementi, M.

AU - Sampaolo, M.

AU - Ceresola, E. R.

AU - Racca, S.

AU - Lazzarin, A.

AU - Castagna, A.

PY - 2015

Y1 - 2015

N2 - In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

AB - In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

KW - HIV-1 DNA load

KW - KPCR

KW - Residual viraemia

KW - Virological failure

KW - Virological rebound

UR - http://www.scopus.com/inward/record.url?scp=84926288041&partnerID=8YFLogxK

U2 - 10.1016/j.cmi.2014.08.004

DO - 10.1016/j.cmi.2014.08.004

M3 - Article

C2 - 25636935

AN - SCOPUS:84926288041

SN - 1198-743X

VL - 21

SP - 103.e7-103.e10

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 1

ER -

HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

Abstract

Keywords

Access to Document

Fingerprint

Cite this