HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti, F. Canducci, L. Galli, F. Cossarini, S. Salpietro, A. Poli, S. Nozza, V. Spagnuolo, M. Clementi, M. Sampaolo, E. R. Ceresola, S. Racca, A. Lazzarin, A. Castagna

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

Original languageEnglish
Pages (from-to)103.e7-103.e10
JournalClinical Microbiology and Infection
Volume21
Issue number1
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • HIV-1 DNA load
  • KPCR
  • Residual viraemia
  • Virological failure
  • Virological rebound

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