HIV and bone loss

Shitij Arora; Manasi Agrawal; Li Sun; Frantz Duffoo; Mone Zaidi; Jameel Iqbal

doi:10.1007/s11914-010-0036-x

HIV and bone loss

Shitij Arora, Manasi Agrawal, Li Sun, Frantz Duffoo, Mone Zaidi, Jameel Iqbal

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.

Original language	English
Pages (from-to)	219-226
Number of pages	8
Journal	Current Osteoporosis Reports
Volume	8
Issue number	4
DOIs	https://doi.org/10.1007/s11914-010-0036-x
State	Published - Dec 2010

Keywords

AIDS
BMD
Bone loss
HIV
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Nucleoside reverse transcriptase inhibitors (NRTIs)
Protease inhibitors

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10.1007/s11914-010-0036-x

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title = "HIV and bone loss",

abstract = "The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.",

keywords = "AIDS, BMD, Bone loss, HIV, Non-nucleoside reverse transcriptase inhibitors (NNRTIs), Nucleoside reverse transcriptase inhibitors (NRTIs), Protease inhibitors",

author = "Shitij Arora and Manasi Agrawal and Li Sun and Frantz Duffoo and Mone Zaidi and Jameel Iqbal",

note = "Funding Information: Drs. Mone Zaidi and Li Sun acknowledge the National Institutes of Health for support (AG 23176, DK70526, and DK80459). Drs. Manasi Agrawal and Jameel Iqbal acknowledge prior support from the American Federation for Aging Research.",

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doi = "10.1007/s11914-010-0036-x",

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AU - Arora, Shitij

AU - Agrawal, Manasi

AU - Sun, Li

AU - Duffoo, Frantz

AU - Zaidi, Mone

AU - Iqbal, Jameel

N1 - Funding Information: Drs. Mone Zaidi and Li Sun acknowledge the National Institutes of Health for support (AG 23176, DK70526, and DK80459). Drs. Manasi Agrawal and Jameel Iqbal acknowledge prior support from the American Federation for Aging Research.

PY - 2010/12

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N2 - The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.

AB - The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.

KW - AIDS

KW - BMD

KW - Bone loss

KW - HIV

KW - Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

KW - Nucleoside reverse transcriptase inhibitors (NRTIs)

KW - Protease inhibitors

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DO - 10.1007/s11914-010-0036-x

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JO - Current Osteoporosis Reports

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HIV and bone loss

Abstract

Keywords

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