HIV-1 virological synapse is not simply a copycat of the immunological synapse

Gaia Vasiliver-Shamis, Michael L. Dustin, Catarina E. Hioe

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion. The VS has been postulated to resemble, in its morphology, the well-studied immunological synapse (IS). This review article discusses the structural similarities between IS and VS and the shared T cell receptor (TCR) signaling components that are found in the VS. However, the IS and the VS display distinct kinetics in disassembly and intracellular signaling events, possibly leading to different biological outcomes. Hence, HIV-1 exploits molecular components of IS and TCR signaling machinery to trigger unique changes in cellular morphology, migration, and activation that facilitate its transmission and cell-to-cell spread.

Original languageEnglish
Pages (from-to)1239-1260
Number of pages22
JournalViruses
Volume2
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • CD4 T lymphocyte
  • HIV
  • HIV envelope
  • HIV-1
  • Immunological synapse
  • T cell receptor
  • Virological synapse
  • gp120

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