Histopathologic evaluation of basilar artery atherosclerosis

Artak Labadzhyan, Laszlo Csiba, Navneet Narula, Jun Zhou, Jagat Narula, Mark Fisher

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Introduction: There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. Methods: To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Results: Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Conclusions: Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalJournal of the Neurological Sciences
Volume307
Issue number1-2
DOIs
StatePublished - 15 Aug 2011
Externally publishedYes

Keywords

  • Artery
  • Atherosclerosis
  • Basilar
  • Intracranial
  • Plaque
  • Stroke

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