Histone deacetylase inhibitors and hemoglobin F induction in β-thalassemia

Anna Rita Migliaccio, Dante Rotili, Angela Nebbioso, George Atweh, Antonello Mai

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations

Abstract

Epigenomic modifiers, such as histone deacetylase inhibitors, are compounds that regulate gene expression by interfering with the enzymatic machinery that maintains the proper chromatin structure of the nucleus. These compounds are at the forefront of novel therapeutic agents for the treatment of several diseases including cancer and genetic disorders such as β-thalassemia and sickle cell disease. Here we review the current understanding of the mechanism of action of epigenomic modifiers in the treatment of β-thalassemia and sickle cell anemia. We also discuss how the lessons learned from the study of the effects of these compounds on the β-globin locus, one of the best characterized regions of the human genome, might contribute to the understanding of the mechanism of action of these same compounds in cancer, where the specific regions of the genome that are responsible for the pathophysiology of the disease are often poorly defined.

Original languageEnglish
Pages (from-to)2341-2347
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume40
Issue number11
DOIs
StatePublished - 2008

Keywords

  • Hemoglobin F induction
  • Histone deacetylase inhibitors
  • β-Globin locus
  • β-Thalassemia

Fingerprint

Dive into the research topics of 'Histone deacetylase inhibitors and hemoglobin F induction in β-thalassemia'. Together they form a unique fingerprint.

Cite this