Histology-specific FGFR2 alterations and FGFR2-TACC2 fusion in mixed adenoid cystic and neuroendocrine small cell carcinoma of the uterine cervix

Corey M. Gill, Theofano Orfanelli, Lorene Yoxtheimer, Christine Roy-McMahon, Jessa Suhner, Shannon Tomita, Tamara Kalir, Yuxin Liu, Jane Houldsworth, Valentin Kolev

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Neuroendocrine small cell carcinoma of the uterine cervix portends a dismal prognosis with limited treatment options. Rarely, tumors of mixed-lineage appear in gynecologic malignancies. Here, we report a 77-year-old woman who presented with complete uterine prolapse and 4-month history of vaginal bleeding. Histopathologic evaluation revealed a mixed adenoid cystic carcinoma and neuroendocrine small cell carcinoma of the uterine cervix. The tumor was PD-L1 and HPV 35 positive. The patient was treated with up-front surgery and adjuvant radiation. Independent, histology-specific alterations in FGFR2 and a FGFR2-TACC2 fusion were identified. Progression of disease occurred within 6 months for which she received chemotherapy and immunotherapy. However, the patient expired within a year. We comprehensively review how screening for and targeting of FGFR alterations in recurrent and metastatic cervical cancer might serve as a touchstone for future treatment regimens.

Original languageEnglish
Article number100668
JournalGynecologic Oncology Reports
Volume34
DOIs
StatePublished - Nov 2020

Keywords

  • Adenoid cystic carcinoma
  • Cervical neoplasm
  • Cervix
  • Precision medicine
  • Procidentia
  • Small cell carcinoma

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