Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature

Amy Huang, Nikki S. Vyas, Stephen E. Mercer, Robert G. Phelps

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Atypical spiradenoma and spiradenocarcinoma present a diagnostic challenge. We aim to assess the significance of certain histologic features, which may facilitate diagnosis of these tumors. Methods: A natural language search for cases of “atypical spiradenoma” and “spiradenocarcinoma” diagnosed between 2009 and 2018 was performed. Original slides were retrieved and a subset of cases (n = 5) were stained for Ki-67, p53, carcinoembryonic antigen (CEA), and S100. All cases (n = 7) were assessed for overall architecture, atypical mitotic figures, abnormal cytology, necrosis, ductal proliferation, dilated vessels, and loss of dual cell population. Results: All our cases showed an abrupt transition from benign to malignant morphology, nuclear atypia, atypical mitotic figures, and a monomorphic loss of the dual cell population (7/7; 100%). The majority also had dilated vessels (6/7; 85.7%), and ductal dilation or proliferation (5/7; 71.4%). Fewer cases showed tumor encapsulation (3/7; 43%), massive necrosis (3/7; 43%), and focal cellular necrosis (1/7; 14%). All cases showed a relatively increased Ki-67 proliferation index at the transitional interface (5/5; 100%). Almost all cases stained positively for p53 (4/5; 80%). Malignant areas of tumor or at the transitional interface showed more intense S100 staining (3/5; 60%). All cases were negative for CEA. Conclusion: Histologic features that strongly favor atypical spiradenoma or spiradenocarcinoma include abrupt transition to malignant foci, atypical mitotic figures, and monomorphic loss of the dual cell population. Ki-67, p53, and S100 may help delineate areas of atypical or malignant transformation in spiradenomas.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalJournal of Cutaneous Pathology
Issue number4
StatePublished - Apr 2019


  • CEA
  • Ki67
  • S100
  • adnexal carcinoma
  • adnexal tumors
  • histology
  • p53
  • spiradenocarcinoma


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