Histocompatibility and immunologic competence in renal homotransplantation

Albert L. Rubin; Kurt H. Stenzel; Kurt Hirschhorn; Fritz Bach

doi:10.1126/science.143.3608.815

Histocompatibility and immunologic competence in renal homotransplantation

Albert L. Rubin, Kurt H. Stenzel, Kurt Hirschhorn, Fritz Bach

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15 Scopus citations

Abstract

Cultures of peripheral lymphocytes may be used to assay histocompatibility. The lymphocytes from potential kidney recipients are cultured with those from potential donors and the percentage of large cells and mitoses stimulated is determined. The immunologic competence of cultured lymphocytes from recipients receiving immunosuppressive therapy is evaluated by determining their responsiveness to phytohemagglutinin. Suppression of response appears to be correlated with the absence of clinical signs of graft rejection.

Original language	English
Pages (from-to)	815-816
Number of pages	2
Journal	Science
Volume	143
Issue number	3608
DOIs	https://doi.org/10.1126/science.143.3608.815
State	Published - 1964
Externally published	Yes

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title = "Histocompatibility and immunologic competence in renal homotransplantation",

abstract = "Cultures of peripheral lymphocytes may be used to assay histocompatibility. The lymphocytes from potential kidney recipients are cultured with those from potential donors and the percentage of large cells and mitoses stimulated is determined. The immunologic competence of cultured lymphocytes from recipients receiving immunosuppressive therapy is evaluated by determining their responsiveness to phytohemagglutinin. Suppression of response appears to be correlated with the absence of clinical signs of graft rejection.",

author = "Rubin, {Albert L.} and Stenzel, {Kurt H.} and Kurt Hirschhorn and Fritz Bach",

year = "1964",

doi = "10.1126/science.143.3608.815",

language = "English",

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AU - Rubin, Albert L.

AU - Stenzel, Kurt H.

AU - Hirschhorn, Kurt

AU - Bach, Fritz

PY - 1964

Y1 - 1964

N2 - Cultures of peripheral lymphocytes may be used to assay histocompatibility. The lymphocytes from potential kidney recipients are cultured with those from potential donors and the percentage of large cells and mitoses stimulated is determined. The immunologic competence of cultured lymphocytes from recipients receiving immunosuppressive therapy is evaluated by determining their responsiveness to phytohemagglutinin. Suppression of response appears to be correlated with the absence of clinical signs of graft rejection.

AB - Cultures of peripheral lymphocytes may be used to assay histocompatibility. The lymphocytes from potential kidney recipients are cultured with those from potential donors and the percentage of large cells and mitoses stimulated is determined. The immunologic competence of cultured lymphocytes from recipients receiving immunosuppressive therapy is evaluated by determining their responsiveness to phytohemagglutinin. Suppression of response appears to be correlated with the absence of clinical signs of graft rejection.

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DO - 10.1126/science.143.3608.815

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SN - 0036-8075

VL - 143

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JO - Science

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Histocompatibility and immunologic competence in renal homotransplantation

Abstract

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