Histochemical study of posterior cricoarytenoid muscle reinnervation by a nerve-muscle pedicle in the cat

Joseph J. Fata, Leslie T. Malmgren, Richard Dum, Richard R. Gacek, Peak Woo

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Reinnervation of the posterior cricoarytenoid (PCA) muscle with a nerve-muscle pedicle (NMP) has been proposed for patients with bilateral abductor vocal cord paralysis. Since its success has been controversial, a glycogen depletion histochemical technique was used to examine reinnervation. An ansa cervicalis NMP was implanted into the denervated PCA in nine cats. Eight months later, vocal cord activity was evaluated. The NMP nerve was stimulated extensively in seven cats (experimental group). Optical densities of NMP-supphed PCA muscle fibers from experimental and control groups were compared to detect differences in glycogen content. The results demonstrated quantitative evidence of reinnervation in two experimental animals. Electrical stimulation of the NMP produced abduction in one of these two animals, but was never observed during spontaneous respiration or airway occlusion. These observations indicate that reinnervation can occur but abduction requires electrical stimulation. The NMP technique may be more successful with an electrical pacer.

Original languageEnglish
Pages (from-to)479-487
Number of pages9
JournalAnnals of Otology, Rhinology and Laryngology
Volume96
Issue number5
DOIs
StatePublished - Sep 1987
Externally publishedYes

Keywords

  • glycogen depletion
  • nerve muscle pedicle
  • posterior cricoarytenoid muscle

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