TY - JOUR
T1 - Histiocytic cytophagic panniculitis
T2 - Molecular evidence for a clonal T-cell disorder
AU - Hytiroglou, Prodromos
AU - Phelps, Robert G.
AU - Wattenberg, Debra J.
AU - Strauchen, James A.
PY - 1992
Y1 - 1992
N2 - Histiocytic cytophagic panniculitis is a systemic disease of unknown etiopathogenesis that invariably involves the subcutaneous fat and is histologically characterized by phagocytosis of blood elements by histiocytes that appear to be benign. Immunophenotypic and genotypic studies of biopsy specimens of the lesions of a 58-year-old woman showed that the lymphocytic infiltrates accompanying the histiocytes in the subcutis were composed of clonal T-cells with rearrangement of the surface receptor gene. Our findings suggest that the primary abnormality in histiocytic cytophagic panniculitis may be a clonal T-cell proliferation.
AB - Histiocytic cytophagic panniculitis is a systemic disease of unknown etiopathogenesis that invariably involves the subcutaneous fat and is histologically characterized by phagocytosis of blood elements by histiocytes that appear to be benign. Immunophenotypic and genotypic studies of biopsy specimens of the lesions of a 58-year-old woman showed that the lymphocytic infiltrates accompanying the histiocytes in the subcutis were composed of clonal T-cells with rearrangement of the surface receptor gene. Our findings suggest that the primary abnormality in histiocytic cytophagic panniculitis may be a clonal T-cell proliferation.
UR - http://www.scopus.com/inward/record.url?scp=0026751120&partnerID=8YFLogxK
U2 - 10.1016/0190-9622(92)70194-K
DO - 10.1016/0190-9622(92)70194-K
M3 - Article
C2 - 1476545
AN - SCOPUS:0026751120
SN - 0190-9622
VL - 27
SP - 333
EP - 336
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -