Histaminergic Angioedema

Paula J. Busse, Tukisa Smith

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Angioedema is frequently categorized into histamine- or bradykinin-mediated disease. It is critical to determine the underlying mediator of symptoms as it directs treatment. Histaminergic angioedema is the most frequent cause of angioedema. It is classified as either acute (lasting <6 weeks) or chronic (symptoms >6 weeks). It is further classified into angioedema presenting with or without urticaria. Some patients with acute angioedema may have disease that becomes chronic. Mast cells and basophils are central to the underlying pathophysiology of histamine-mediated angioedema. The underlying treatments of histamine-mediated angioedema are antihistamines, corticosteroids, and epinephrine.

Original languageEnglish
Pages (from-to)467-481
Number of pages15
JournalImmunology and Allergy Clinics of North America
Issue number3
StatePublished - Aug 2017


  • Angioedema
  • Histamine
  • Histaminergic
  • Inducible urticaria
  • Spontaneous urticaria
  • Urticaria


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