Hippocampectomy and feature-positive discrimination

Karen J. Loechner, Donald J. Weisz

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18 Scopus citations


The effects of hippocampal lesions on feature-positive discrimination were investigated using the nictitating membrane response preparation. During training, animals received a simultaneous reinforced compound as the conditioned stimulus (CS+) and a non-reinforced element as the CS -. The compound consisted of a tone and a light, with the tone being more salient than the light. The light and tone served as the CS - in Expts. 1 and 2, respectively. There were no significant differences between hippocampectomized animals and the controls (cortical and sham) when the CS - was the light; however, when the more salient tone stimulus was the CS -, hippocampectomized animals exhibited high levels of responding to both the CS+ and CS - and failed to acquire the discrimination. The results are discussed in terms of attentional and response inhibition theories of hippocampal function.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalBehavioural Brain Research
Issue number1
StatePublished - Oct 1987
Externally publishedYes


  • Feature-positive discrimination
  • Hippocampus
  • Nictitating membrane
  • Rabbit


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