Hippocampal 1H-MRSI in ecstasy users

Thomas Obergriesser; Gabriele Ende; Dieter F. Braus; Fritz A. Henn

doi:10.1007/s004060170044

Hippocampal ¹H-MRSI in ecstasy users

Thomas Obergriesser, Gabriele Ende, Dieter F. Braus, Fritz A. Henn

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In recent years the illicit drug ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) has come into widespread use among young people. Despite clear evidence for the neurotoxic potential of MDMA in animals, corresponding evidence in humans is limited to indirect findings. In an exploratory study we compared the hippocampal ¹H-MRSI (magnetic resonance spectroscopic imaging) spectra of five MDMA users with those of controls with no history of substance abuse. Although ¹H-MRSI is sensitive in detecting alterations in neuronal viability in association with diseases leading to neuronal degeneration, we were not able to demonstrate any differences in hippocampal ¹H-MRSI between MDMA users and controls.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	251
Issue number	3
DOIs	https://doi.org/10.1007/s004060170044
State	Published - 2001
Externally published	Yes

Keywords

3,4-methylenedioxymethamphetamine
Hippocampus
Nuclear magnetic resonance

Access to Document

10.1007/s004060170044

Cite this

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title = "Hippocampal 1H-MRSI in ecstasy users",

abstract = "In recent years the illicit drug ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) has come into widespread use among young people. Despite clear evidence for the neurotoxic potential of MDMA in animals, corresponding evidence in humans is limited to indirect findings. In an exploratory study we compared the hippocampal 1H-MRSI (magnetic resonance spectroscopic imaging) spectra of five MDMA users with those of controls with no history of substance abuse. Although 1H-MRSI is sensitive in detecting alterations in neuronal viability in association with diseases leading to neuronal degeneration, we were not able to demonstrate any differences in hippocampal 1H-MRSI between MDMA users and controls.",

keywords = "3,4-methylenedioxymethamphetamine, Hippocampus, Nuclear magnetic resonance",

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journal = "European Archives of Psychiatry and Clinical Neuroscience",

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T1 - Hippocampal 1H-MRSI in ecstasy users

AU - Obergriesser, Thomas

AU - Ende, Gabriele

AU - Braus, Dieter F.

AU - Henn, Fritz A.

PY - 2001

Y1 - 2001

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AB - In recent years the illicit drug ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) has come into widespread use among young people. Despite clear evidence for the neurotoxic potential of MDMA in animals, corresponding evidence in humans is limited to indirect findings. In an exploratory study we compared the hippocampal 1H-MRSI (magnetic resonance spectroscopic imaging) spectra of five MDMA users with those of controls with no history of substance abuse. Although 1H-MRSI is sensitive in detecting alterations in neuronal viability in association with diseases leading to neuronal degeneration, we were not able to demonstrate any differences in hippocampal 1H-MRSI between MDMA users and controls.

KW - 3,4-methylenedioxymethamphetamine

KW - Hippocampus

KW - Nuclear magnetic resonance

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JO - European Archives of Psychiatry and Clinical Neuroscience

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