Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer disease

Liana G. Apostolova, Amity E. Green, Sona Babakchanian, Kristy S. Hwang, Yi Yu Chou, Arthur W. Toga, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

226 Scopus citations

Abstract

Alzheimer disease (AD) is the most common type of dementia worldwide. Hippocampal atrophy and ventricular enlargement have been associated with AD but also with normal aging. We analyzed 1.5-T brain magnetic resonance imaging data from 46 cognitively normal elderly individuals (NC), 33 mild cognitive impairment and 43 AD patients. Hippocampal and ventricular analyses were conducted with 2 novel semiautomated segmentation approaches followed by the radial distance mapping technique. Multiple linear regression was used to assess the effects of age and diagnosis on hippocampal and ventricular volumes and radial distance. In addition, 3-dimensional map correction for multiple comparisons was made with permutation testing. As expected, most significant hippocampal atrophy and ventricular enlargement were seen in the AD versus NC comparison. Mild cognitive impairment patients showed intermediate levels of hippocampal atrophy and ventricular enlargement. Significant effects of age on hippocampal volume and radial distance were seen in the pooled sample and in the NC and AD groups considered separately. Age-associated differences were detected in all hippocampal subfields and in the frontal and body/occipital horn portions of the lateral ventricles. Aging affects both the hippocampus and lateral ventricles independent of AD pathology, and should be included as covariate in all structural, hippocampal, and ventricular analyses when possible.

Original languageEnglish
Pages (from-to)17-27
Number of pages11
JournalAlzheimer Disease and Associated Disorders
Volume26
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Alzheimer disease
  • aging
  • hippocampal atrophy
  • lateral ventricle enlargement
  • mild cognitive impairment

Fingerprint

Dive into the research topics of 'Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer disease'. Together they form a unique fingerprint.

Cite this