Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes

Juan A. González-Vera; Francisco Fueyo-González; Ibon Alkorta; Marion Peyressatre; May C. Morris; Rosario Herranz

doi:10.1039/c6cc04566a

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes

Juan A. González-Vera
, Francisco Fueyo-González
, Ibon Alkorta
, Marion Peyressatre
, May C. Morris
, Rosario Herranz

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.

Original language	English
Pages (from-to)	9652-9655
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	62
DOIs	https://doi.org/10.1039/c6cc04566a
State	Published - 2016
Externally published	Yes

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title = "Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes",

abstract = "Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.",

author = "Gonz{\'a}lez-Vera, \{Juan A.\} and Francisco Fueyo-Gonz{\'a}lez and Ibon Alkorta and Marion Peyressatre and Morris, \{May C.\} and Rosario Herranz",

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T1 - Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold

T2 - Novel CDK5 probes

AU - González-Vera, Juan A.

AU - Fueyo-González, Francisco

AU - Alkorta, Ibon

AU - Peyressatre, Marion

AU - Morris, May C.

AU - Herranz, Rosario

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.

AB - Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.

UR - https://www.scopus.com/pages/publications/84979911610

U2 - 10.1039/c6cc04566a

DO - 10.1039/c6cc04566a

M3 - Article

C2 - 27383006

AN - SCOPUS:84979911610

SN - 1359-7345

VL - 52

SP - 9652

EP - 9655

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes

Abstract

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