Highlight: BRCA1 and BRCA2 proteins in breast cancer

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Heterozygous carriers of loss-of-function germline mutations in the BRCA1 or BRCA2 breast cancer susceptibility genes have a predisposition to breast and ovarian cancer. Multiple functions have been ascribed to the products of these genes, linking them to pathways that inhibit progression to neoplasia. Various investigators have assigned roles for these tumor suppressor gene products in the cell functions of genome repair, transcription, and growth control. There is emerging evidence that BRCA1 may participate in ubiquitin E3 ligase activity. BRCA1 and BRCA2 have each been implicated in chromatin remodeling dynamics via protein partnering. Ubiquitin ligase and chromatin remodeling activities need not be mutually exclusive and both may function in DNA repair, transcriptional regulation, or cell cycle control. Here we highlight certain recent findings and currently unanswered questions regarding BRCA1 and BRCA2 in breast cancer.

Original languageEnglish
Pages (from-to)68-83
Number of pages16
JournalMicroscopy Research and Technique
Issue number1
StatePublished - 1 Oct 2002


  • BRCT domain
  • Cell cycle checkpoint
  • Chromatin remodeling
  • DNA damage response
  • DNA repair
  • E3 ligase
  • RING finger
  • Tumor suppressor
  • Ubiquitination


Dive into the research topics of 'Highlight: BRCA1 and BRCA2 proteins in breast cancer'. Together they form a unique fingerprint.

Cite this