Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk

Samira Asgari, Yang Luo, Chuan Chin Huang, Zibiao Zhang, Roger Calderon, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Leonid Lecca, David Jones, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105 patients with TB and 1,320 household contacts (HHCs) who were infected with Mycobacterium tuberculosis (M. tb) but did not develop TB and inferred each individual's proportion of native Peruvian genetic ancestry. Our HHC study design and our data on potential confounders allowed us to demonstrate increased risk independent of socioeconomic factors. A 10% increase in individual-level native Peruvian genetic ancestry proportion corresponded to a 25% increased TB progression risk. This corresponds to a 3-fold increased risk for individuals in the highest decile of native Peruvian genetic ancestry versus the lowest decile, making native Peruvian genetic ancestry comparable in effect to clinical factors such as diabetes. Our results suggest that genetic ancestry is a major contributor to TB progression risk and highlight the value of including diverse populations in host genetic studies.

Original languageEnglish
Article number100151
JournalCell Genomics
Volume2
Issue number7
DOIs
StatePublished - 13 Jul 2022

Keywords

  • Native American
  • Peru
  • TB
  • TB progression
  • admixture
  • genetic ancestry
  • genotyping
  • host genomics
  • infectious diseases
  • population genetics
  • tuberculosis

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