High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

Tiago G. Fernandes; Maria Margarida Diogo; Douglas S. Clark; Jonathan S. Dordick; Joaquim M.S. Cabral

doi:10.1016/j.tibtech.2009.02.009

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

Tiago G. Fernandes
, Maria Margarida Diogo
, Douglas S. Clark
, Jonathan S. Dordick
, Joaquim M.S. Cabral

Research output: Contribution to journal › Review article › peer-review

258 Scopus citations

Abstract

Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.

Original language	English
Pages (from-to)	342-349
Number of pages	8
Journal	Trends in Biotechnology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.tibtech.2009.02.009
State	Published - Jun 2009
Externally published	Yes

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title = "High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research",

abstract = "Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.",

author = "Fernandes, \{Tiago G.\} and Diogo, \{Maria Margarida\} and Clark, \{Douglas S.\} and Dordick, \{Jonathan S.\} and Cabral, \{Joaquim M.S.\}",

note = "Funding Information: T.G.F. acknowledges support from Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, Portugal (BD/24365/2005). J.S.D. and D.S.C. acknowledge support from the National Institutes of Health (ES012619 and GM66712).",

year = "2009",

month = jun,

doi = "10.1016/j.tibtech.2009.02.009",

language = "English",

volume = "27",

pages = "342--349",

journal = "Trends in Biotechnology",

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T2 - applications in drug discovery, toxicology and stem cell research

AU - Fernandes, Tiago G.

AU - Diogo, Maria Margarida

AU - Clark, Douglas S.

AU - Dordick, Jonathan S.

AU - Cabral, Joaquim M.S.

N1 - Funding Information: T.G.F. acknowledges support from Fundação para a Ciência e a Tecnologia, Portugal (BD/24365/2005). J.S.D. and D.S.C. acknowledge support from the National Institutes of Health (ES012619 and GM66712).

PY - 2009/6

Y1 - 2009/6

N2 - Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.

AB - Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.

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DO - 10.1016/j.tibtech.2009.02.009

M3 - Review article

C2 - 19398140

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JO - Trends in Biotechnology

JF - Trends in Biotechnology

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High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

Abstract

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