@article{3397ab6c55aa4fd7a13d7ad7bd4b7163,
title = "High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development",
abstract = "Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 {\AA}), S-adenosylhomocysteine (1.55 {\AA}) and sinefungin (1.41 {\AA}). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.",
author = "Jithesh Kottur and Olga Rechkoblit and Richard Quintana-Feliciano and Daniela Sciaky and Aggarwal, {Aneel K.}",
note = "Funding Information: We thank the staff at the National Synchrotron Light Source II (NSLS-II) beamlines 17-ID-1 and 17-ID-2 for facilitating X-ray data collection. This work was funded by grant R35-GM13170 (A.K.A) from the National Institutes of Health (NIH). NSLS-II is a United States Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under Contract No. DE-SC0012704. The Center for BioMolecular Structure (CBMS) at NSLS-II is primarily supported by the NIH, National Institute of General Medical Sciences (NIGMS) through a Center Core P30 Grant (P30GM133893), and by the DOE Office of Biological and Environmental Research (KP1605010). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2022",
month = sep,
doi = "10.1038/s41594-022-00828-1",
language = "English",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
}