High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development

Jithesh Kottur, Olga Rechkoblit, Richard Quintana-Feliciano, Daniela Sciaky, Aneel K. Aggarwal

Research output: Contribution to journalArticlepeer-review

Abstract

Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 Å), S-adenosylhomocysteine (1.55 Å) and sinefungin (1.41 Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.

Original languageEnglish
JournalNature Structural and Molecular Biology
DOIs
StatePublished - Sep 2022

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