High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development

Jithesh Kottur; Olga Rechkoblit; Richard Quintana-Feliciano; Daniela Sciaky; Aneel K. Aggarwal

doi:10.1038/s41594-022-00828-1

High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development

Jithesh Kottur, Olga Rechkoblit, Richard Quintana-Feliciano, Daniela Sciaky, Aneel K. Aggarwal

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 Å), S-adenosylhomocysteine (1.55 Å) and sinefungin (1.41 Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.

Original language	English
Pages (from-to)	850-853
Number of pages	4
Journal	Nature Structural and Molecular Biology
Volume	29
Issue number	9
DOIs	https://doi.org/10.1038/s41594-022-00828-1
State	Published - Sep 2022

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title = "High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development",

abstract = "Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 {\AA}), S-adenosylhomocysteine (1.55 {\AA}) and sinefungin (1.41 {\AA}). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.",

author = "Jithesh Kottur and Olga Rechkoblit and Richard Quintana-Feliciano and Daniela Sciaky and Aggarwal, {Aneel K.}",

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AU - Kottur, Jithesh

AU - Rechkoblit, Olga

AU - Quintana-Feliciano, Richard

AU - Sciaky, Daniela

AU - Aggarwal, Aneel K.

PY - 2022/9

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AB - Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 Å), S-adenosylhomocysteine (1.55 Å) and sinefungin (1.41 Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.

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SP - 850

EP - 853

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 9

ER -

High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development

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