High prevalence of MMTV-like env gene sequences in gestational breast cancer

Y. Wang, S. M. Melana, B. Baker, I. Bleiweiss, M. Fernandez-Cobo, J. F. Mandeli, J. F. Holland, B. G.T. Pogo

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30-38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalMedical Oncology
Volume20
Issue number3
DOIs
StatePublished - 2003

Keywords

  • Gestational breast cancer
  • MMTV sequences

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