Abstract
Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30-38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.
Original language | English |
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Pages (from-to) | 233-236 |
Number of pages | 4 |
Journal | Medical Oncology |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - 2003 |
Keywords
- Gestational breast cancer
- MMTV sequences