High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease

Joyce E. Yu, Suk See De Ravin, Gulbu Uzel, Carol Landers, Stephan Targan, Harry L. Malech, Steven M. Holland, Wenqing Cao, Noam Harpaz, Lloyd Mayer, C. Cunningham-Rundles Charlotte

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) have overlapping gastrointestinal manifestations. Serum antibodies to intestinal microbial antigens in IBD are thought to reflect a loss of tolerance in the setting of genetically encoded innate immune defects. CGD subjects studied here, with or without colitis, had considerably higher levels of ASCA IgA, ASCA IgG, anti-OmpC, anti-I2, and anti-CBir1, but absent to low pANCA, compared to IBD-predictive cutoffs. Higher antibody levels were not associated with a history of colitis. Except for higher ASCA IgG in subjects < 18. years, antibody levels were not age-dependent. In comparison, 7 HIES subjects expressed negative to low antibody levels to all of these antigens; none had colitis. Our results suggest that markedly elevated levels of antimicrobial antibodies in CGD do not correlate with a history of colitis but may reflect a specific defect in innate immunity in the face of chronic antigenic stimulation.

Original languageEnglish
Pages (from-to)14-22
Number of pages9
JournalClinical Immunology
Volume138
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Chronic granulomatous disease
  • Colitis
  • Hyper IgE Syndrome
  • Inflammatory bowel disease
  • Innate immunity
  • Serum antimicrobial antibodies

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