TY - GEN
T1 - High-frequency, vector-flow imaging in the left ventricle of FHF2 deficient murine heart
AU - Ketterling, Jeffrey A.
AU - Shekhar, Akshay
AU - Fishman, Glenn I.
AU - Aristizabal, Orlando
AU - Phoon, Colin K.L.
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/9/7
Y1 - 2020/9/7
N2 - The left ventricle (LV) of fibroblast growth factor homologous factor 2 (FHF2)-deficient (Fhf2KO/Y) and wild-type Fhf2WT/Y mice were imaged with high-speed, plane-wave methods using an 18-MHz linear array. Fhf2KO/Y present with hyperthermia-induced ECG abnormalities highly reminiscent of Brugada syndrome. Data were acquired at three transmission angles [-5, 0 5 degrees] at a rate of 30 kHz for a 1 sec duration while the core temperature of the mice were raised to 41.5° C. The data were processed to obtain vector-flow estimates, vorticity and pericardium motion at the far wall of the LV. The hemodynamics and pericardial-motion of the Fhf2WT/Y and Fhf2KO/Y mice were compared as a function of temperature. Above 40° C the Fhf2KO/Y mouse displayed disrupted flow patterns and greater beat-to-beat variation relative to the Fhf2WT/Y mouse.
AB - The left ventricle (LV) of fibroblast growth factor homologous factor 2 (FHF2)-deficient (Fhf2KO/Y) and wild-type Fhf2WT/Y mice were imaged with high-speed, plane-wave methods using an 18-MHz linear array. Fhf2KO/Y present with hyperthermia-induced ECG abnormalities highly reminiscent of Brugada syndrome. Data were acquired at three transmission angles [-5, 0 5 degrees] at a rate of 30 kHz for a 1 sec duration while the core temperature of the mice were raised to 41.5° C. The data were processed to obtain vector-flow estimates, vorticity and pericardium motion at the far wall of the LV. The hemodynamics and pericardial-motion of the Fhf2WT/Y and Fhf2KO/Y mice were compared as a function of temperature. Above 40° C the Fhf2KO/Y mouse displayed disrupted flow patterns and greater beat-to-beat variation relative to the Fhf2WT/Y mouse.
KW - Cardiac function
KW - Doppler
KW - High-frequency ultrasound
KW - Plane-wave ultrasound imaging
KW - Small-animal imaging
KW - Vortex dynamics
UR - http://www.scopus.com/inward/record.url?scp=85097883493&partnerID=8YFLogxK
U2 - 10.1109/IUS46767.2020.9251834
DO - 10.1109/IUS46767.2020.9251834
M3 - Conference contribution
AN - SCOPUS:85097883493
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2020 - International Ultrasonics Symposium, Proceedings
PB - IEEE Computer Society
T2 - 2020 IEEE International Ultrasonics Symposium, IUS 2020
Y2 - 7 September 2020 through 11 September 2020
ER -