High-frequency ultrasound of extranodal limbal Rosai-Dorfman disease: Affecting the conjunctiva, sclera, and cornea

Paul T. Finger, Henry D. Perry, Sanford Kempin, Codrin E. Iacob

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


PURPOSE: To correlate the clinical, high-frequency ultrasound, and pathology characteristics of an epibulbar Rosai-Dorfman tumor. METHODS: We report a case of a steroid-resistant yellow perilimbal epibulbar tumor referred for ophthalmic oncology evaluation. It was documented by slit-lamp photography and evaluated by high-frequency ultrasound. A hematology-oncology evaluation and excisional biopsy were performed. RESULTS: Ophthalmic examination revealed a solitary yellow perilimbal epibulbar tumor. High-frequency ultrasound imaging revealed low internal reflectivity and partial-thickness scleral and corneal invasion with no extension into the anterior segment. Primary excision was performed. Although histopathology revealed large atypical histiocytes, immunochemistry found them to be both S-100 positive and CD1a negative (diagnostic of Rosai-Dorfman disease). Hematology-oncology evaluation revealed no systemic disease or links to human herpesvirus. Local control required cryotherapy and sub-Tenon steroid injection. CONCLUSIONS: Epibulbar Rosai-Dorfman tumors can invade the sclera and are often treated by surgical excision. High-frequency ultrasound imaging should be used to determine the presence or extent of invasion before surgery.

Original languageEnglish
Pages (from-to)888-890
Number of pages3
Issue number7
StatePublished - Aug 2007
Externally publishedYes


  • High-frequency ultrasound
  • Histiocytosis
  • Limbus
  • Rosai-Dorfman
  • Tumor
  • Ultrasound biomicroscopy


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