TY - JOUR
T1 - High circulating caspase-cleaved keratin 18 fragments (M30) indicate short-term mortality in critically ill patients
AU - Koch, Alexander
AU - Yagmur, Eray
AU - Linka, Janine
AU - Schumacher, Fabienne
AU - Bruensing, Jan
AU - Buendgens, Lukas
AU - Herbers, Ulf
AU - Koek, Ger H.
AU - Weiskirchen, Ralf
AU - Trautwein, Christian
AU - Tacke, Frank
N1 - Publisher Copyright:
© 2018 Alexander Koch et al.
PY - 2018
Y1 - 2018
N2 - Caspase-cleaved fragments of the intermediate filament protein keratin 18 (cytokeratin-18 (CK18)) can be detected in serum as M30 levels and may serve as a circulating biomarker indicating apoptosis of epithelial and parenchymal cells. In order to evaluate M30 as a biomarker in critical illness, we analyzed circulating M30 levels in 243 critically ill patients (156 with sepsis, 87 without sepsis) at admission to the medical intensive care unit (ICU), in comparison to healthy controls (n = 32). M30 levels were significantly elevated in ICU patients compared with healthy controls. Circulating M30 was closely associated with disease severity but did not differ between patients with sepsis and ICU patients without sepsis. M30 serum levels were correlated with biomarkers of inflammation, cell injury, renal failure, and liver failure in critically ill patients. Patients that died at the ICU showed increased M30 levels at admission, compared with surviving patients. A similar trend was observed for the overall survival. Regression analyses confirmed that M30 levels are associated with mortality, and patients with M30 levels above 250.8 U/L displayed an excessive short-term mortality. Thus, our data support the utility of circulating levels of the apoptosis-related keratin fragment M30 as a prognostic biomarker at ICU admission.
AB - Caspase-cleaved fragments of the intermediate filament protein keratin 18 (cytokeratin-18 (CK18)) can be detected in serum as M30 levels and may serve as a circulating biomarker indicating apoptosis of epithelial and parenchymal cells. In order to evaluate M30 as a biomarker in critical illness, we analyzed circulating M30 levels in 243 critically ill patients (156 with sepsis, 87 without sepsis) at admission to the medical intensive care unit (ICU), in comparison to healthy controls (n = 32). M30 levels were significantly elevated in ICU patients compared with healthy controls. Circulating M30 was closely associated with disease severity but did not differ between patients with sepsis and ICU patients without sepsis. M30 serum levels were correlated with biomarkers of inflammation, cell injury, renal failure, and liver failure in critically ill patients. Patients that died at the ICU showed increased M30 levels at admission, compared with surviving patients. A similar trend was observed for the overall survival. Regression analyses confirmed that M30 levels are associated with mortality, and patients with M30 levels above 250.8 U/L displayed an excessive short-term mortality. Thus, our data support the utility of circulating levels of the apoptosis-related keratin fragment M30 as a prognostic biomarker at ICU admission.
UR - http://www.scopus.com/inward/record.url?scp=85055664965&partnerID=8YFLogxK
U2 - 10.1155/2018/8583121
DO - 10.1155/2018/8583121
M3 - Article
C2 - 30069276
AN - SCOPUS:85055664965
SN - 0278-0240
VL - 2018
JO - Disease Markers
JF - Disease Markers
M1 - 8583121
ER -