Heterotrimeric G proteins: Insights into the neurobiology of mood disorders

Javier González-Maeso, J. Javier Meana

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR) pathways have been reported in the etiopathology of mood disorders and the suicidal behavior. In this regard, the implication of certain GPCR subtypes such as α2A-adrenoceptor has been repeatedly described using different approaches. However, several discrepancies have been recently reported in density and functional status of the heterotrimeric G proteins both in major depression and bipolar disorder. A compilation of the most relevant research topics about the implication of heterotrimeric G proteins in the etiology of mood disorders (i.e., animal models of mood disorders, studies in peripheral tissue of depressive patients, and studies in postmortem human brain of suicide victims with mood disorders) will provide a broad perspective of this potential therapeutic target field. Proposed causes of the discrepancies reported at the level of G proteins in postmortem human brain of suicide victims will be discussed.

Original languageEnglish
Pages (from-to)127-138
Number of pages12
JournalCurrent Neuropharmacology
Volume4
Issue number2
DOIs
StatePublished - Apr 2006

Keywords

  • Bipolar disorder
  • G protein-coupled receptors (GPCR)
  • Heterotrimeric G proteins
  • Major depression
  • Mood disorders
  • Suicide
  • α -adrenoceptors

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