Heterotopic pregnancy including intrauterine normal gestation and tubal complete hydatidiform mole: A case report and review of the literature

Dan Lu, Jian Jenny Tang, Konstantin Zakashansky, Ross S. Berkowitz, Tamara Kalir, Yuxin Liu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We report a rare case of heterotopic pregnancy with intrauterine normal gestation alongside tubal complete hydatidiform mole (CHM) that resulted in a viable pregnancy after removal of molar tissue. Because of their rarity and inherent complexity, such cases represent a significant challenge in diagnosis and management. A 34-year-old female in her 10th week of gestation presented with nausea, vomiting, and intermittent abdominal pain that progressively worsened. Imaging studies revealed a normal intrauterine fetus and an 11-cm heterogenous mass in the left adnexal region. The patient's serum human chorionic gonadotropin was higher than the reference range. Diagnostic laparoscopy revealed a large hemorrhagic mass involving the left adnexa that was removed completely. The mass was composed of blood clots admixed with necrotic tissue of vesicular appearance on gross inspection. Microscopic examination revealed large chorionic villi with circumferential trophoblastic proliferation and cisterns, all of which are characteristic of CHM. An implantation site was identified at the tubal fimbriae. Immunohistochemistry p57 demonstrated negative staining in the villous stromal and cytotrophoblastic cells, supporting the diagnosis of CHM. Chromosomal karyotyping and cytogenetic analysis were performed on chorionic villi samples from the intrauterine gestation and reported as normal (46, XX). The patient elected to continue the intrauterine pregnancy, delivering a healthy female infant at 39 weeks. Our case reaffirms that to successfully manage this rare yet life-threatening condition, heterotopic pregnancy should be included in the differential diagnosis for any gravid women presenting with persistent abdominal pain and/or extrauterine mass.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalInternational Journal of Gynecological Pathology
Issue number5
StatePublished - 2017
Externally publishedYes


  • Complete hydatidiform mole
  • Heterotopic pregnancy
  • P57


Dive into the research topics of 'Heterotopic pregnancy including intrauterine normal gestation and tubal complete hydatidiform mole: A case report and review of the literature'. Together they form a unique fingerprint.

Cite this