Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction

Purpose: To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging. Materials and methods: Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LS_regional, LS_global, CS_regional, CS_global), and their regional heterogeneities were evaluated using coefficients of variation (LS_CoV, CS_CoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%. Results: LS_global in HCM patients was significantly decreased compared to that in controls (− 14.4 ± 2.4% vs − 17.2 ± 2.0%; p = 0.0004), while CS_global was not (p = 1.0). Negative LGE segments demonstrated decreased LS_regional in HCM patients compared to in controls (p < 0.0001), while CS_regional was not decreased. CS_CoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LS_CoV was low (0.49). Conclusion: The heterogeneity in CS_regional has a high diagnostic value for detection of HCM patients with extensive LGE.