Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration

Lap Ho, Ling Hong Chen, Jun Wang, Wei Zhao, Stephen T. Talcott, Kenjiro Ono, David Teplow, Nelson Humala, Alice Cheng, Susan S. Percival, Mario Ferruzzi, Elsa Janle, Dara L. Dickstein, Giulio Maria Pasinetti

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


We recently found that moderate consumption of two un-related red wines generate from different grape species, a Cabernet Sauvignon and a muscadine wine that are characterized by distinct component composition of polyphenolic compounds, significantly attenuated the development of Alzheimer's disease (AD)-type brain pathology and memory deterioration in a transgenic AD mouse model. Interestingly, our evidence suggests that the two red wines attenuated AD phenotypes through independent mechanisms. In particular, we previously found that treatment with Cabernet Sauvignon reduced the generation of AD-type beta-amyloid (Aβ) peptides. In contrast, evidence from our present study suggests that muscadine treatment attenuates Aβ neuropathology and Aβ-related cognitive deterioration in Tg2576 mice by interfering with the oligomerization of Aβ molecules to soluble high-molecular-weight Aβ oligomer species that are responsible for initiating a cascade of cellular events resulting in cognitive decline. Collectively, our observations suggest that distinct polyphenolic compounds from red wines may be bioavailable at the organism level and beneficially modulate AD phenotypes through multiple Aβ-related mechanisms. Results from these studies suggest the possibility of developing a "combination" of dietary polyphenolic compounds for AD prevention and/or therapy by modulating multiple Aβ-related mechanisms.

Original languageEnglish
Title of host publicationHandbook of Animal Models in Alzheimer's Disease
EditorsGemma Casadesus
Number of pages13
StatePublished - 2011

Publication series

NameAdvances in Alzheimer's Disease
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735


  • Alzheimer's disease dementia
  • amyloid-β protein precursor (AβPP)
  • high-molecular weight amyloid-β oligomer species
  • polyphenols


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