TY - JOUR
T1 - Heterodimerization of G-protein-coupled receptors
T2 - Pharmacology, signaling and trafficking
AU - Devi, Lakshmi A.
N1 - Funding Information:
I would like to thank Bryen Jordan and Ivone Gomes for critical reading of the manuscript and Clyde Scott for help with the illustrations. This work was supported in part by NIH grant K02 DA-00458.
PY - 2001/10/1
Y1 - 2001/10/1
N2 - Although classical models predict that G-protein-coupled receptors (GPCRs) function as monomers, several recent studies acknowledge that GPCRs exist as dimeric or oligomeric complexes. In addition to homodimers, heterodimers between members of the GPCR family (both closely and distantly related) have been reported. In some cases heterodimerization is required for efficient agonist binding and signaling, and in others heterodimerization appears to lead to the generation of novel binding sites. In this article, the techniques used to study GPCR heterodimers, and the 'novel pharmacology' and functional implications resulting from heterodimerization will be discussed.
AB - Although classical models predict that G-protein-coupled receptors (GPCRs) function as monomers, several recent studies acknowledge that GPCRs exist as dimeric or oligomeric complexes. In addition to homodimers, heterodimers between members of the GPCR family (both closely and distantly related) have been reported. In some cases heterodimerization is required for efficient agonist binding and signaling, and in others heterodimerization appears to lead to the generation of novel binding sites. In this article, the techniques used to study GPCR heterodimers, and the 'novel pharmacology' and functional implications resulting from heterodimerization will be discussed.
UR - http://www.scopus.com/inward/record.url?scp=0035478438&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(00)01799-5
DO - 10.1016/S0165-6147(00)01799-5
M3 - Review article
C2 - 11583811
AN - SCOPUS:0035478438
SN - 0165-6147
VL - 22
SP - 532
EP - 537
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 10
ER -